Priyanka Srinivasan, M.Sc.

Priyanka Srinivasan, M.Sc., Orthopaedic Research Laboratory (ORL) Nijmegen, RUN MC Priyanka.SrinivasanAapjeradboudumc.nl
T: +31 (0) 24 36 55288
About Me
Research Impression
Publications

About Me

I was born in India and after finishing high school my family and I moved to Enschede in 2002. In the years to follow, I obtained a Bachelors and Masters degree in Mechanical Engineering at the University of Twente. During the course of my masters program, I did my masters thesis work at the Orthopaedic Research Laboratory Nijmegen. This was a time of personal growth and learning, which I thoroughly enjoyed. It became clear to me during this period that a career in an orthopaedics related field was the way forward. After graduation in 2010, I decided to work in industry and develop as an engineer. I was fortunate to find a position as a product development engineer and later, project manager at Spierings Orthopaedics, Nijmegen. In 2013, I decided to pursue a PhD to further improve my academic credentials and started as a PhD student at the ORL from the 1st of August. This Ph.D. research is part of an international research consortium funded by the National Institutes of Health (NIH). My supervisor is Dennis Janssen
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Research Impression

In total knee replacement, implant components can be fixated in the body using bone cement. Although total knee replacement is a successful orthopaedic intervention, the reconstruction eventually will fail, requiring revision surgery. The aim of this project is to investigate how the process of implant loosening can be postponed.

This project is a collaborative effort of the Department of Orthopedics of the SUNY Upstate Medical University in Syracuse, NY, and the Orthopaedic Research Laboratory (ORL) of the Radboud University Nijmegen Medical Centre. Within this project, experimental techniques (SUNY Upstate) are combined with computational modeling (ORL) to study the load transfer mechanisms and motion at the level of the bone trabeculae (~1mm) and below, see figure 1.

We have been performing in vitro experiments on small components of bone-implant interfaces in which small (micron scale) loading is applied in tension, compression, and shear. We incorporate digital image correlation techniques to map local strain fields subjected to loading. The long-term goal here is to improve our understanding of local motions at the interface and how motion is related to bony response, by combining information from experimental and computational models on laboratory prepared and post-mortem retrieved specimens.

One of my tasks is to include computational modeling of the cement-bone interface of cement tibial knee implants.
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Research of Priyanka Srinivasan, Orthopaedic Research Laboratory (ORL) Nijmegen, UMCN

Figure 1 A) schematic drawing of a bone cement interface; B) 3-dim Computer Model of a bone cement interface; C) histological image of a bone cement interface at a cellular level; D) FE-Model of image C);

Publications

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