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In 1988 I started my master thesis in Nijmegen at the Orthopaedic Research Laboratory (ORL). Mid 1989 I received my M.Sc. in (Bio-)Mechanical Engineering from the University of Twente. Ever since my graduation I stayed at the ORL.
As Junior Researcher I performed various kinds of projects focussing on testing of orthopaedic implants. Most projects were funded by the Orthopaedic Industry which gradually led to an extensive network of R&D departments from small to large international orthopaedic companies. The publications of these projects resulted in my Ph.D. degree in 1995 on a thesis entitled “Biomechanical Failure Scenarios in Cemented Total Hip Replacement”.
Subsequently I was promoted to Assistant Professor and was appointed to be Director of Pre-clinical testing of joint implants. In 2003 I was further promoted to Associate Professor. In October 2007 I started a part-time appointment (1 day per week) at the University of Twente, where I have set up a research line related to clinical biomechanics of the musculoskeletal system in collaboration with my clinical colleagues at the Radboud Medical Centre. Since February 2014 I am a full professor in Biomechanical diagnostics and evaluation methods in orthopaedics at the Radboud university medical center. Since September 1st 2015, I’m chair of the ORL.
In December 2012 I was awarded a ‘European Research Council – Advanced Grant’ entiteld ‘Biomechanical Diagnostic, Pre-Planning and Outcome Tools to improve Musculoskeletal Surgery’, acronym ‘BioMechTools’.
Over the last years I focused on setting up a strong research line concerning computer simulations of implants, fracture prediction of weakened bones and musculoskeletal modeling. This research line is multi-dimensional, including finite element computer simulations, experimental testing, in-vivo kinematics and musculoskeletal modeling. Currently I am coordinator of an EU-STREP (FP7) project which is aimed at predicting the functional effect of tumor surgery on the musculoskeletal system by using musculoskeletal models (see www.tlemsafe.eu ). In December 2012 I obtained a five year ERC Advance Grant which allows us to expand our work on personalized modeling of the lower extremity, see our research ‘ERC BioMechTools‘.
Clinical areas in which our group has made major contributions are: functional analysis of knee and hip (revision) patients, ligament reconstruction, computer navigation, clinical/functional effects of long bone fractures, treatment of cartilage and meniscus defects, reconstruction of bony defects around implants, fracture fixation devices, evaluation of biomaterials, improving imaging based orthopedic surgery, designing implants and developing instruments for minimal invasive surgery.
In the computer modeling area our group has contributed on topics as: the effect of muscle loads on the survival of implants, the simulation of peri-prosthetic bone remodeling, the simulation of the micro-mechanics of the cement-bone interface, the time-dependent creep and fatigue behavior of bone cement, the ingrowth process of bone into coated implants, the fracture simulation of bones that are weakened due to cancer, the kinematic behavior of knee prostheses and the sensitivity of musculoskeletal models to small changes in muscle parameters.
- My Thesis: Biomechanical Failure Scenarios for Cemented Total Hip Replacement
- See PubMed
- ThomsonReuters ResearcherID citations H-8104-2014 Verdonschot N.J.J.
- ThomsonReuters Web of Science
- See researchgate.net
- search Google Scholar for ‘N Verdonschot’
- See NARCIS – National Academic Research and Collaborations Information System
TLEMsafe – patient-specific surgical navigation