Prediction of fracture risk in patients with metastatic lesions
Prediction of fracture risk is very difficult but clinically extremely important for patients suffering osteoporosis or metastasized cancer in the skeleton. Bone metastases occur in about 15% of all cancer cases. Patients with bone metastases have an increased fracture risk due to weakening of the bone. Particularly, fractures of the femur have large impact on the quality of life. In our research lab, we aim to improve the prediction of femoral fracture risk in patients with bone metastases by developing patients specific computer models, i.e. non-linear finite element models.
We will perform two research phases. Phase 1 covers the development and validation of a predictive computer model to calculate bone strength. Phase 2 covers the determination of the sensitivity and the specificity of the predictive computer model using prospective clinical data.
Yvette van der Linden (LUMC, Leiden)
2015 November 19th