Biomechanical Diagnostic, Pre-Planning and Outcome Tools to improve Musculoskeletal Surgery
Within the BioMechTools programme we will develop diagnostic and evaluation tools to quantify the degenerative status of orthopaedic patients. Our focus lies on the lower extremities. This project will open new research fields related to biomechanical patient assessment and modelling of musculoskeletal pathologies.
The aetiology of many musculoskeletal diseases is related to biomechanical factors. However, the tools used by clinicians and researchers to assess the biomechanical condition of patients are often crude and subjective, leading to non-optimal patient analyses and care. For example, clinicians usually base their diagnosis on their own, subjective, interpretation of static imaging data like MRI-images and CT-scans. Yet, it is much more powerful to visualize the pathological tissue in a dynamic manner, i.e. a tear in a meniscus is easier to see when the meniscus is moving than when it is imaged statically.
The Orthopaedic Research Laboratory, in collaboration with the Department of Biomechanical Engineering (University of Twente), has been very successful in delivering imaging modalities and in generating patient specific musculoskeletal and finite element models. These types of models can be used to analyse the pathology in detail and to assess the biomechanical consequences of various surgical scenarios. See, for example, our research line ‘Musculoskeletal Biomechanics‘ and the ‘TLEMsafe‘ project.
With the BioMechTools project we aim to develop MRI and Ultrasound tools to quantify tissue strains under dynamic circumstances. Innovations related to imaging, sensor technology and biomechanical modelling will be utilized to generate versatile, accurate and objective methods to quantify the (pathological) musculoskeletal condition of the lower extremity of patients in a unique manner. These advanced diagnostic, pre-planning and outcome tools will provide clinicians and researchers with detailed biomechanical analysis about abnormal tissue deformations, pathological loading of the joints, abnormal stresses in the hard and soft tissues, and aberrant joint kinematics.
Our research will be done in collaboration with the BioMedical NMR group of the Technical University of Eindhoven and the Radiology department of the Academic Medical Centre Amsterdam for the dynamic MRI imaging and with the ‘Medical UltraSound Imaging Center‘ of the Radboudumc for the ultrasound techniques.
Our key objectives are:
- develop and validate image based 3-D volumetric elastographic diagnostic methods that can quantify normal and pathological conditions of tissues under dynamic loading and which can be linked to biomechanical modelling tools
- create an ultrasound-based system to assess internal joint kinematics which can be used as a diagnostic tool for clinicians and researchers and which is a validation tool for biomechanical modelling
- generate and validate an ambulant functional (force and kinematic) diagnostic system which is easy to use and which can be used to provide input data for biomechanical models
- create and validate a new modelling approach that integrates muscle-models with finite element models at a highly personalized level
- generate biomechanical models which have personalized mechanical properties of the hard and soft tissues
- demonstrate the applicability of the personalized diagnostic and pre-planning platform by application to healthy individuals and to patients
Nico Verdonschot, Prof. Dr. Ir.
André Sprengers, Ph.D.
Hamid Naghibi-Beidokhti, Ph.D.
Marco Marra, M.Sc.
BioMedical NMR group
Radiology: Novel MRI techniques
Klaas Nicolay, Prof. Dr.
Gustav Strijkers, Dr. Ir.
A.J. Nederveen, Dr. Ir.
Valentina Mazzoli, Ph.D.
Medical UltraSound Imaging Center
Chris de Korte, Prof. Dr.
Kaj Gijsbertse, Ph.D.
Department of Biomechanical Engineering
Biomedical Signals And Systems
Bart Koopman, Prof. Dr. Ir.
Peter H. Veltink, Prof. Dr. Ir.
Kenan Niu, Ph.D.
Victor Sluiter, B.Eng.
Prof. Dr. Ir. Nico Verdonschot
The European Research Council (ERC-Advanced Grant)
60 months (from May 2013)
2018 February 15th
2017 December 6th
Functional MRI of the Lower Extremities.
List of articles
Gijsbertse K, Sprengers AM, Nillesen MM, Hansen HH, Lopata RG, Verdonschot N, de Korte CL.
Phys Med Biol. 2017 Jan 21;62(2):596-611
Epub 2016 Dec 29
Oudeman J, Mazzoli V, Marra MA, Nicolay K, Maas M, Verdonschot N, Sprengers AM, Nederveen AJ, Strijkers GJ, Froeling M.
Physiol Rep. 2016 Dec; 4(24). pii: e13012.
PMID: 28003562 Free PMC Article
Mazzoli V, Oudeman J, Nicolay K, Maas M, Verdonschot N, Sprengers AM, Nederveen AJ, Froeling M, Strijkers GJ.
NMR Biomed. 2016 Dec; 29(12):1813-1824
Naghibi Beidokhti H, Janssen D, Khoshgoftar M, Sprengers A, Perdahcioglu ES, Van den Boogaard T, Verdonschot N.
Med Eng Phys. 2016 Oct; 38(10):1123-30
Mazzoli V, Nederveen AJ, Oudeman J, Sprengers A, Nicolay K, Strijkers GJ, Verdonschot N.
Magn Reson Med. 2016 Jul 15
Marra MA, Vanheule V, Fluit R, Koopman BH, Rasmussen J, Verdonschot N, Andersen MS.
J Biomech Eng. 2015 Feb 1;137(2):020904