Tissue Engineering of a Meniscus

In Vitro Tissue Engineering of a Meniscus

In this project we will develop a tissue engineered meniscus based on resorbable polymer scaffolds. In the past we used isotropic scaffolds for this purpose. This did not lead to the desired results. Differentiated tissue in the scaffold did not had the typical appearance of the anisotropic meniscus tissue. In this project we will develop a new class of polymers. The hypothesis is that if we develop scaffolds with an anisotropic pore structure, cells will differentiate into the anisotropic meniscus tissue. Cells that are used are goat meniscus fibrocytes. The surface of the polymer will be modified to be able to attach relevant growth factors. Mechanical stimulation of constructs will be performed in a bioreactor (Bose system). For more information on this project see the web-page of:

STW-project ‘A Functional Tissue-Regenerating Meniscus Implant’
Project-Leader Pieter Buma Prof. Ph.D.
Surgeon Tony van Tienen, M.D. / Ph.D.
Former Ph.D.-student Jan Rongen Ph.D., M.D.
Former Ph.D.-student Eric de Mulder Ph.D.
schematic meniscus scaffold by orthopaedic research laboratory nijmegen

Scheme showing the Circumferential Orientation of the Pores in the Meniscus Scaffold.

meniscus fig.1C: Micro-CT visualization of porous structure with diamond pore network; Jan Rongen, Orthopaedic Research Laboratory Nijmegen, RUN MC

Micro-CT Visualization of a Mathematically Designed Porous Elastic Meniscus Structure.

meniscus implant by orthopaedic research laboratory Nijmegen

Example of a Meniscus Implant.

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