TLEMsafe Patient-specific surgical navigation film showcases the TLEMsafe project. The film shows the case of a patient who needs to undergo a major orthopaedic intervention, including the placement of a large prosthesis. Note: Images may be shocking to some audiences. The TLEMsafe project, “Twente Lower Extremity Model for safe and predictable musculoskeletal surgery”, aims to develop a patient-specific surgical […]

Implant fixation of a PEEK total knee arthroplasty

Figure 1. Example of a finite element analysis on the femoral component of a total knee arthroplasty. Total knee arthroplasty (TKA) is a widely used surgical procedure to restore the knee joint after cartilage disorders as osteoarthritis. During this surgical procedure, the damaged cartilage layer is removed and the bones are cut in the correct […]

The effect of interference fit on the primary fixation of cementless TKA components

Finite element analysis and cadaveric experiments to investigate the fixation of two types of implants with different interference fit. Total Knee Arthroplasty (TKA) is the most common and successful surgical procedure for a diseased knee joint, offering pain relief and improvement of knee function, and providing a better quality of life for patients. The surgery […]

Fracture prediction in femoral bone metastases using the BOne Strength (BOS) Score

We developed the BOne Strength (BOS) Score, an easy-to-use tool to assess fracture risk of patients with femoral bone metastases. Patients with advanced cancer often develop bone metastases, and in approximately ten percent, these lesions occur in the femur. Femoral metastases may cause pain and can lead to pathological fractures, which severely affect the quality […]


Develop and implement a highly patient specific decision aid for patients with hip- or knee osteoarthritis Hip- and knee osteoarthritis are leading causes of disability resulting in joint pain and stiffness. Total hip- and knee arthroplasty (THA and TKA) are a recommended intervention when conservative management appears to be ineffective and disability is significant. Due […]


Patients with metastatic bone disease can suffer from severe pain, pathological fractures of long bones or even spinal cord compression. For these patients, the main focus is on improving their quality of life by providing pain relief and preserving function. At the moment, in order to destroy these lesions, there are two methods available: external […]