Ph.D. defence Marco Marra, April 16th 2019;

This thesis is part of
Marco Marra M.Sc. | Ph.D. student for the ERC project BioMechTools | Orthopaedic Research Laboratory Nijmegen, radboudumc, Radboud University Nijmegen Medical Centre.


Prof.Dr.Ir. N.J.J. Verdonschot
Prof.Dr.Ir. H.F.J.M. Koopman
University of Twente


Dr.Ir. D.W. Janssen Radboudumc

Personalized Musculoskeletal Modeling of the Knee Joint.

This research develops computer models to simulate the knee function, and can predict the effect of surgical interventions. Thanks to the use of medical images, accurate geometrical representations of patients’ anatomy are obtained, from which patient-specific models can be made. Such models are used to simulate the effect of different surgical techniques or implant alignment in total knee replacement surgery, thus aiding orthopedic surgeons in the planning of orthopedic interventions. Personalized models were used to further understand the causes of muscle weakness in patients with a muscular dystrophy. It is expected that, when applied to larger patient groups, this personalized model-based approach will help clinicians formulating more optimized clinical decisions tailored to each patient’s needs. For this to occur, personalized models need to be further developed, become easier to generate and operate, and build their credibility in the clinical setting by continuous validation.

Marco Marra graduated in 2013 in Biomedical Engineering from Politecnico di Torino (Italy). He worked on his doctoral research, within the European project BioMechTools, at the Orthopaedic Research Lab of Radboud University Medical Center. He is currently Assistant Professor at the Biomechanical Engineering department of the University of Twente, where he does research and teaches in the field of biomechanics.

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