In Vitro Tissue Engineering of a Meniscus
In this project we will develop a tissue engineered meniscus based on resorbable polymer scaffolds. In the past we used isotropic scaffolds for this purpose. This did not lead to the desired results. Differentiated tissue in the scaffold did not had the typical appearance of the anisotropic meniscus tissue. In this project we will develop a new class of polymers. The hypothesis is that if we develop scaffolds with an anisotropic pore structure, cells will differentiate into the anisotropic meniscus tissue. Cells that are used are goat meniscus fibrocytes. The surface of the polymer will be modified to be able to attach relevant growth factors. Mechanical stimulation of constructs will be performed in a bioreactor (Bose system).
For more information on this project see the web-page of:
|Start: January 1st, 2013||End: May 31st, 2018|
|Project-Leader||Pieter Buma Prof. Ph.D.|
|Surgeon||Tony van Tienen, M.D. / Ph.D.|
|Former Ph.D.-student||Jan Rongen Ph.D., M.D.|
|Former Ph.D.-student||Eric de Mulder Ph.D.|